About 220 potential jurors reported for duty Tuesday, after the court whittled the number to about 600 based on answers to questionnaires sent to prospective jurors' homes. Of those, about half were sent home and asked to return Wednesday.
"We are now making good progress," Judge John Cleland said late Tuesday afternoon.
Twelve jurors and four alternates will eventually be selected.
The 68 year old Sandusky has been under house arrest since being charged with sexually abusing 10 boys for at least 15 years.
Opening statements are expected to begin Monday, the judge said, and the trial is likely to last about three weeks.
Prosecutors plan to call more than 50 witnesses during the trial, and the defense plans to call about 100, including Jay and Sue Paterno, Joe Paterno's son and widow; McQueary; his father, John; and Spanier, among others.